Functional identity of a primer recognition protein as phosphoglycerate kinase.
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چکیده
منابع مشابه
Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase.
The yeast Saccharomyces cerevisae has four distinct mitogen-activated protein kinase kinases (MAPKKs), each of which has a distinct functional identity characterized by communication with specific upstream and downstream partners to form distinct functional pathways. These four kinases belong to one family, sharing closely related catalytic domains. How have these four related kinases diverged ...
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powder; cold-acid hydrolysed; hot-acid hydrolysed. In addition there was a significant quantity of metabolites remaining water-soluble after all forms of hydrolysis. 4. When 1 or 2 hr. fractions of bile were analysed the proportion of radioactivity excreted as glucuronide always decreased in successive samples, whereas water-soluble metabolites generally increased. In some animals the proportio...
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-1. The phosphoglycerate kinase electrophoretic banding patterns of several Drosophila species were studied. 2. Three banding types were noted: A type with a slowly migrating band of activity, a type with a faster migrating band of activity, and a type with an intermediate migrating band. 3. These banding types appeared to be species specific and may be useful in evolutionary or taxonomical stu...
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Eby, D. & Kirtley, M. E. (1971) Biochemistry 10,2677-2682 Fuller-Noel, J. K. & Schumaker, V. W. (1972) J. Mol. Biol. 68,523-532 Gennis, L. S. (1976) Proc. Natl. Acad. Sci. U.S.A. 73, 3928-3932 Harrigan, P. J. & Trenthami, D. R. (1971) Biochem. J . 124, 573-580 Hams, J. I. & Polgar, L. (1965) J. Mol. Biol. 14, 630-633 Harris, J. I. & Waters, M. (1976) Enzymes 3rd Ed. 23, 1-50 Kirschner, K. (1971...
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Sulfhydryl reagents, as well as mild hydrogen peroxide oxidation, do not inhibit the activity of yeast phosphoglycerate kinase, indicating that the single thiol group and 3 methionine residues present in the enzyme are not essential for activity. Nitration of phosphoglycerate kinase by tetranitromethane inhibits the enzyme by reaction with a single tyrosine residue. Substrates provide partial p...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1990
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)39179-3